According to a paper published in Aging on November 18, 2020, a study led by Professor Shai Efrati of the Sackler School of Medicine found that a unique protocol of treatments with high-pressure oxygen in a hyperbaric pressure chamber can reverse two major processes associated with aging and its illnesses. Focusing on immune cells containing DNA obtained from the participants’ blood, the study discovered a lengthening of up to 38% of the telomeres, as well as a decrease of up to 37% in the presence of senescent cells. The paper follows a clinical trial was conducted as part of a comprehensive Israeli research program that targets aging as a reversible condition.
“For many years our team has been engaged in hyperbaric research and therapy – treatments based on protocols of exposure to high-pressure oxygen at various concentrations inside a pressure chamber,” Professor Efrati explains. “Our achievements over the years included the improvement of brain functions damaged by age, stroke or brain injury.
“In the current study we wished to examine the impact of hyperbaric oxygen therapy on healthy and independent aging adults, and to discover whether such treatments can slow down, stop or even reverse the normal aging process at the cellular level.”
The researchers exposed 35 healthy individuals aged 64 or over to a series of 60 hyperbaric sessions over a period of 90 days. Each participant provided blood samples before, during and at the end of the treatments as well as some time after the series of treatments concluded. The researchers then analyzed various immune cells in the blood and compared the results.
The findings indicated that the treatments actually reversed the aging process in two of its major aspects: The telomeres at the ends of the chromosomes grew longer instead of shorter, at a rate of 20%-38% for the different cell types; and the percentage of senescent cells in the overall cell population was reduced significantly – by 11%-37% depending on cell type.
Telomere shortening is considered to be one of the primary causes of aging and a lot of effort has gone into finding ways to extend shortened telomeres.
“Until now, interventions such as lifestyle modifications and intense exercise were shown to have some inhibiting effect on telomere shortening,” Dr. Hadanny adds. “But in our study, only three months of HBOT were able to elongate telomeres at rates far beyond any currently available interventions or lifestyle modifications. With this pioneering study, we have opened a door for further research on the cellular impact of HBOT and its potential for reversing the aging process.”
Original source: Eurekalert